Water Quality Indices (WQIs) provide a simplified representation of monitoring data by aggregating several water quality parameters. Horton (1965) developed the first WQI, and since then at least 40 indices have been composed. Fuzzy Clustering (FC) is applied here in order to derive an efficient and flexible WQI. FC is a new approach based on fuzzy logic methodology in which the classification of information is determined by a fuzzy relationship, such as a Max-Min function. After selecting a fuzzy similarity relation, the approach is as follow: a fuzzy similarity matrix is established, the selected fuzzy relationship stabilizes it, a dynamic clustering chart is developed and, given a suitable threshold, the appropriate classification is determined. \nIn this work, the selected classification is related to a reach of the water body and is used to identify zones for water quality management. Therefore a general methodology for FC analysis is developed and illustrated with a case study of water quality evaluation for the Karoon River, the largest river in Iran. Many industrial and municipal point sources and agricultural non-point sources of pollution line the Karoon and have caused a high degree of degradation in the river. Hence, in this paper eleven indicators are analyzed to account for a range of water quality impacts. A significant issue in FC is selection of a suitable distance equation to determine the similarity matrix. In this work this problem is addressed by using four well-known equations: the Wang Peizhuang, Cosine, Single linkage, Tajrishy, Canbera Metric, City Block Metrics, and Minkowski Metrics functions. The results of applications of each of these functions are compared and a suitable method for the Karoon River is identified. Based on these results, water quality zoned maps are prepared.\nUnderstanding large and complex data sets and revealing underlying relations and phenomena, and visualizing major tendencies are too difficult. Making sense of data is an ongoing task of researchers and professionals in almost every practical endeavor. The age of information technology, characterized by a vast array of data, has enormously amplified this quest and made it even more challenging. Data collection anytime and everywhere has become the reality of our lives.